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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Water Proton NMR for Monitoring Sedimentation Process of Multiphase Mixtures
Published Tuesday, June 27, 2023Summary The technology developed by the University of Maryland, Baltimore utilizes water proton Nuclear Magnetic Resonance (NMR) to monitor the sedimentation process in multiphase mixtures in real-time. This analytical method...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Chemicals, Biologics, Vaccines
Keyword(s): Sedimentation Monitoring, Multiphase Mixtures, Water Proton NMR, Pharmaceutical, Specialty Chemical, Specialty Materials
Docket: BY-2020-149
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KCNMA1-D434G Transgenic Mouse Line
Published Thursday, April 27, 2023KCNMA1-D434G knock-in mice express a gain-of-function (GOF) autosomal dominant aspartic acid to glycine substitution at position 434 of the potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (...
Investigator(s): Andrea Meredith
Categories: Research Tools, Antibodies, & Reagents, Genetics
Docket: AM-2019-104
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Kcnma1fl-tdTomato Conditional Knockout Mice
Published Monday, January 9, 2023Kcnma1fl-tdTomato conditional mutant mice possess loxP sites flanking exon 2 and a tdTomato reporter (that only expresses upon cre-recombination) in the Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) gene and may be useful in generating conditional mutations to study the function of BK currents...
Investigator(s): Andrea Meredith
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Molecular Biology; Neuroscience; Genetics; Transgenic mice
Docket: AM-2013-078
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Inverted Culture Plate Insert for Cellular Co-Culture
Published Wednesday, June 27, 2018Lack of metabolic competence is a major limitation for the majority of current high throughput screening (HTS) assays used for screening drugs, environmental chemicals and industrial compounds for toxicity. As many compounds are metabolically transformed in vivo, toxicity assays should reflect physiologically-relevant metabolism to accurately...
Investigator(s): Bryan Mackowiak, Hongbing Wang, Linhao Li
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: BM-2017-002
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Stable Fluorescent Mutant of Perkinsus marinus Expressing GFP
Published Tuesday, May 2, 2017Perkinsus are intracellular parasites that cause disease in shellfish, especially bivalve molluscs. Its infection has devastated oyster populations along the US coasts. In addition to the economic value of shellfisheries, filter-feeding bivalves such as oysters play a critical role in maintaining water quality, making Perkinsus...
Investigator(s): Gerardo R. Vasta, Jose-Antonio Fernandez-Robledo
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Transgenic, protozoan
Docket: GV-2014-015
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Recombinant, Purified P. aeruginosa HemO Enzyme
Published Wednesday, April 5, 2017Pathogenic bacteria require iron for their survival and ability to cause infection. Many bacterial pathogens have evolved sophisticated systems to use heme as a primary source of iron, including Pseudomonas aeruginosa, an opportunistic gram-negative pathogen that is a common cause of nosocomial infections and associated with high...
Investigator(s): Angela Wilks
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Heme oxygenase, heme O, TRP, Research Tool
Docket: AW-2015-091
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Transgenic Ubiquitin (hUBQLN2) Mice Models of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia (ALS-FTD)
Published Monday, March 6, 2017ALS (or Lou Gehrig’s disease) is a progressive neurodegenerative disorder associated with loss of upper and lower motor neurons. A majority of ALS patients (> 90%) die within 2 to 5 years of being diagnosed, usually because of upper respiratory failure. In addition to the hallmark of progressive muscle weakness, up to 15% of patients with...
Investigator(s): Mervyn J. Monteiro
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Molecular Biology; Neuroscience; Genetics; Transgenic mice
Docket: MM-2017-037
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Nano-structured Metal-Enhanced Fluorescence (MEF-spot)-Based Sensing, Imaging and Assay
Published Friday, February 24, 2017This invention describes an improved method for conducting a bioassay using fluorescence intensity or lifetime fluorescent emissions. This new method avoids the need of complex enzymatic and biochemical amplification of the fluorescence signal. Although it has applicability over a wide range of bioassays, the method...
Investigator(s): Henryk Szmacinski, Joseph R. Lakowicz
Categories: Research Tools, Antibodies, & Reagents, Sensors/Monitors
Keyword(s): Cytokine assay, immunoassay
Docket: HS-2012-047, HS-2015-098
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Multi-Functional Fluid Flow Device
Published Tuesday, February 21, 2017Cells within a body are exposed to interstitial fluid movements that stimulate morphologic and biochemical cell changes in response to their environment. The fluid flow device is an inexpensive, multifunctional adapter that fit the wells of traditional tissue culture plates to introduce fluid flow shear stress and...
Investigator(s): James Lyon, Joseph Stains, Christopher Ward
Categories: Research Tools, Antibodies, & Reagents, Microfluidics
Keyword(s): Microfluidics, Research Tool
Docket: JL-2016-052
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Monoclonal antibodies to polycystin-1 protein
Published Monday, October 19, 2015Polycystin-1 (PC1) is a protein encoded by the Polycystic Kidney Disease 1 (PKD1) gene. It induces resistance to apoptosis and spontaneous proliferation of kidney tubular epithelial cells. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease that results in formation of fluid filled cysts in the kidney. As the...
Investigator(s): Feng Qian, Terry Watnick
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): PKD, polycystic kidney disease polycystin-1
Docket: FQ-2015-089