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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Research Tool for Identification of Conditionally Enriched Protein Expression in Bacterial Cells
Published Tuesday, September 22, 2015BackgroundChanges in environmental conditions can drastically change the protein content of cells. The amount of specific proteins (i.e., their expression levels) can increase or decrease quickly in response to these environmental changes in order to insure cell survival. This rapid process happens at the translational and post-...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): 525
Docket: LS-2015-092
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High Affinity PCR Primer System
Published Tuesday, November 4, 2014BackgroundPolymerase chain reaction (PCR) is a biological research technique for the amplification of DNA sequences that has allowed for great advances in genetics. While PCR techniques have been refined over the years, and there has been continued development of the polymerases used in PCR, there are still some limitations to the...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Genetic testing, PCR primers
Docket: LS-2014-045
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3D Printed Molds for 3D Tissue Culture Scaffolds
Published Tuesday, November 4, 2014BackgroundCellular and tissue culture is an important aspect of biological research. Having specific cell or tissue types in a controlled environment allows for development and refinement of the efficacy and safety of biological treatments. However, as researchers study more complex conditions, standard monolayer (2D) cell culture is...
Categories: Biological, Research Tools, Antibodies, & Reagents
Keyword(s): PDMS, stem cells, cell culture, tissue culture
Docket: LS-2014-073
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Microdevice for the Detection of Sequence Differences in Biological Samples
Published Tuesday, November 4, 2014BackgroundWith the advancements in biomedical research, accurate sequencing of biological samples is becoming of greater importance. The completion of the Human Genome Project has highlighted the potential of single nucleotide polymorphisms (SNPs) in DNA while the increase in protein-based therapies has increased interest in the...
Categories: Diagnostics, Devices, Research Tools, Antibodies, & Reagents
Keyword(s): Gene sequencing, protein sequencing, lab-on-chip
Docket: LS-2014-076
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Simplified Synthesis of Polyubiquitin Chains
Published Sunday, July 20, 2014BackgroundUbiquitin is an important protein involved in the post-translational modification and trafficking of other cellular proteins. After attaching a single ubiquitin monomer to a protein, cells use the formation of polyubiquitin chains (attaching more ubiquitin to the initial monomer) to direct if the protein should be inserted into...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Ubiquitin synthesis
Docket: LS-2014-029
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High Affinity Aptamer for Detection of HIV Reverse Transcriptase
Published Tuesday, June 3, 2014BackgroundThe development of multi-drug therapy for HIV has greatly extended the lives of patients undergoing multi-drug therapy. For best results, multi-drug therapy requires early detection and constant monitoring of viral loads in patients. Current technologies for viral load monitoring require dedicated machinery and highly skilled...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): HIV diagnostic, point-of-care
Docket: LS-2014-032
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Self Assembling Inorganic Nanoparticle Vesicles - Building Blocks for Functional Nanomaterials
Published Monday, May 27, 2013Background-Self-assembly is the process by which the components of a preexisting disordered system spontaneously come together as an organized structure or pattern. The self-assembly of nanoparticles composed of two or more different materials into composite nanoparticles offers promising opportunities for synthesizing a variety of...
Categories: Nanotechnology + Nanoparticles + Nanomaterials, Research Tools, Antibodies, & Reagents
Keyword(s): vesicle, inorganic, inorganic material, imaging. theranostic, diagnostic, polymer, asymmetric nanoparticle, nanoparticle, Bioimaging, drug delivery, Catalysis, Optoelectronic devices, Novel building blocks,new functional materials, functional devices, devices, material, nanomaterial, synthesis, nanoparticle, multi-component, 525
Docket: LS-2012-097
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Diagnostic Assay to Study Protein-Nucleic Acid Interactions
Published Tuesday, July 12, 2011BackgroundProtein-nucleic acid interactions including protein-DNA and protein-RNA interactions are crucial to the protection and usage of the genome. There are many methods currently being used to identify and analyze these interactions including filter binding assays, eletrophoretic mobility shift assays (EMSA), Chromatin...
Categories: Research Tools, Antibodies, & Reagents, Platforms, Drug Screen
Keyword(s): Protein-nucleic acid interactions, Protein-DNA interactions, Protein-RNA interactions, High-Throughput, Protein-ligand interactions
Docket: LS-2011-021
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Universal High-Throughput Detection of Protein-Ligand Interactions
Published Monday, October 11, 2010BackgroundThe knowledge of protein-ligand and protein-metabolite interactions has significant implications in modern drug design and use. Since each of these molecular interactions represents a potential pharmaceutical intervention in disease and agriculture, there is an urgent need to collect qualitative and quantitative functional...
Categories: Research Tools, Antibodies, & Reagents, Drug Screen, Platforms
Keyword(s): Protein-Ligand Interaction, Diagnostic Kit to study Protein Ligand Interaction, Diagnostic kit, Biomolecular Interactions
Docket: LS-2010-086
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A Rapid Method for Scanning Amino Acid Mutagenesis
Published Tuesday, April 14, 2009In order to study the relationship between structure and function of a protein, the DNA encoding the protein or its corresponding amino acid is subjected to mutations. A number of methods to mutagenize DNA have been developed including site-directed mutagenesis, linker scanning mutagenesis, and the alanine scanning mutagenesis. The first method...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): mutagenisis, mutation, DNA, amino acid, nucleotide, protein
Docket: LS-2007-026