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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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TLR Inhibitors for Treatment of Influenza, Cancer, Allergy, Inflammation and Prevention of Endotoxic Shock
Published Wednesday, May 28, 2014The Toll-like receptors (TLRs) play a vital role in eradicating pathogenic microbial infections, eliminating necrotic host cells and enhancing tissue repair in the host. On the flip side, chronic TLR activation leads to inflammatory disease and “systemic” activation of TLRs may lead to death. ...
Investigator(s): Vladimir Toshchakov
Categories: Research Tools, Antibodies, & Reagents, Platforms, Therapeutics, Biologics
Keyword(s): TLR, decoy peptides, inflammation, cancer, microbial infections, immune disorders, allergy, endotoxic shock, TRAM, TRIF, TIRAP and MyD88
Docket: VT-2012-029 VT-2012-052
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Fluorescence-Based Assay to Screen for Mitochondrial Protective Compounds
Published Tuesday, May 27, 2014The UMB inventors have developed an enzymatic assay which is a sensitive method for detecting mitochondrial damage. It is based on coupled enzymatic reactions that produce a detectable fluorescence signal in the presence of the reduced or oxidized form of nicotinamide adenine dinucleotide (NADH/NAD) and can detect nanomolar levels of pyridine...
Investigator(s): Tibor Kristian, Gary Fiskum
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: TK-2004-007
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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Self Assembling Inorganic Nanoparticle Vesicles - Building Blocks for Functional Nanomaterials
Published Monday, May 27, 2013Background-Self-assembly is the process by which the components of a preexisting disordered system spontaneously come together as an organized structure or pattern. The self-assembly of nanoparticles composed of two or more different materials into composite nanoparticles offers promising opportunities for synthesizing a variety of...
Categories: Nanotechnology + Nanoparticles + Nanomaterials, Research Tools, Antibodies, & Reagents
Keyword(s): vesicle, inorganic, inorganic material, imaging. theranostic, diagnostic, polymer, asymmetric nanoparticle, nanoparticle, Bioimaging, drug delivery, Catalysis, Optoelectronic devices, Novel building blocks,new functional materials, functional devices, devices, material, nanomaterial, synthesis, nanoparticle, multi-component, 525
Docket: LS-2012-097
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Diagnostic Assay to Study Protein-Nucleic Acid Interactions
Published Tuesday, July 12, 2011BackgroundProtein-nucleic acid interactions including protein-DNA and protein-RNA interactions are crucial to the protection and usage of the genome. There are many methods currently being used to identify and analyze these interactions including filter binding assays, eletrophoretic mobility shift assays (EMSA), Chromatin...
Categories: Research Tools, Antibodies, & Reagents, Platforms, Drug Screen
Keyword(s): Protein-nucleic acid interactions, Protein-DNA interactions, Protein-RNA interactions, High-Throughput, Protein-ligand interactions
Docket: LS-2011-021
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Universal High-Throughput Detection of Protein-Ligand Interactions
Published Monday, October 11, 2010BackgroundThe knowledge of protein-ligand and protein-metabolite interactions has significant implications in modern drug design and use. Since each of these molecular interactions represents a potential pharmaceutical intervention in disease and agriculture, there is an urgent need to collect qualitative and quantitative functional...
Categories: Research Tools, Antibodies, & Reagents, Drug Screen, Platforms
Keyword(s): Protein-Ligand Interaction, Diagnostic Kit to study Protein Ligand Interaction, Diagnostic kit, Biomolecular Interactions
Docket: LS-2010-086
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A Rapid Method for Scanning Amino Acid Mutagenesis
Published Tuesday, April 14, 2009In order to study the relationship between structure and function of a protein, the DNA encoding the protein or its corresponding amino acid is subjected to mutations. A number of methods to mutagenize DNA have been developed including site-directed mutagenesis, linker scanning mutagenesis, and the alanine scanning mutagenesis. The first method...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): mutagenisis, mutation, DNA, amino acid, nucleotide, protein
Docket: LS-2007-026
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Precision Bandmaster
Published Wednesday, March 5, 2008Researchers at the University of Maryland have invented a new gel-cutting device for use in molecular biology.This device, the Bandmaster, is unlike any other gel-cutting device currently available in that it allows accurate viewing of the band from above, which can greatly reduce the possibility of contamination. Unlike most other...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): gel device gel-cutting comb bandmaster band
Docket: LS-2006-072
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‘Sashi’ Agar- Agar for the Specific Detection of Salmonella and Shigella
Published Sunday, November 12, 2006Researchers have developed a single plating agar that detects both Shigella and Salmonella species. Importantly, the new agar is capable of doing this with greater sensitivity and specificity, for both agents, than other agars in common use. The new agar, because of its ability to efficiently detect two major human pathogens, appears to...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Microbiological media, agar, Salmonella, shigella
Docket: LS-2006-034
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Nuclease Deficient RecBCD Enzyme
Published Monday, February 2, 2004Researchers at the University of Maryland have isolated a set of plasma borne genes that encode three forms of a bacterial enzyme that unwinds double-stranded DNA very rapidly and with high processivity. The enzyme is also a nuclease that breaks down one or both strands of the DNA. The researches have mutated the gene so that it lacks detectable...
Categories: Research Tools, Antibodies, & Reagents, Biologics
Keyword(s): nuclease, double-stranded DNA, mutation
Docket: LS-2003-060