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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Gallium-salophen Antimicrobial Compounds and Methods of Use Thereof
Published Wednesday, May 24, 2023Summary Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, causes life-threatening infections. Multidrug resistant Pa has been classified by the CDC as a “serious...
Investigator(s): Fengtian Xue, Angela Wilks
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): pharmaceuticals, Clinical Medicine, Antimicrobial Compounds
Docket: FX-2020-101
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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Detection of Pharmaceutical Product Freezing History using Water Proton NMR
Published Wednesday, May 17, 2023Summary Researchers at UMB have created an innovative method that employs water proton nuclear magnetic resonance (NMR) spectroscopy to detect the freezing history of pharmaceutical products. This technology compares the...
Investigator(s): Bruce Yu, Marc Traban, Katharine Briggs
Categories: Devices, Therapeutics, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2019-081
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Prodrugs of anti-cancer and anti-autoimmune diseases therapeutic agents, and methods of making and use thereof
Published Wednesday, May 17, 2023Summary In summary, the invention disclosed by UMB investigators offers a promising new approach to the treatment of cancer and autoimmune diseases by introducing a series of novel prodrugs with improved safety and efficacy...
Investigator(s): Fengtian Xue, Yan Shu, Yong Li
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Prodrug, cancer, Autoimmune, Therapeutic
Docket: FX-2019-033
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Wnt Signaling Pathway Inhibitors for Treatments of Disease
Published Wednesday, May 17, 2023Summary UMB inventors have developed compounds that inhibit the Wnt/β-catenin signaling pathway, which is implicated in various diseases, including cancer and metabolic disorders such as type 2 diabetes, obesity,...
Investigator(s): Fengtian Xue, Yan Shu
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): cancer, Metabolic Disease, diabetes
Docket: FX-2015-082
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Compounds for Treating Parasitic Infections
Published Monday, May 15, 2023Summary Researchers at the University of Maryland, Baltimore and the University of Maryland, College Park have synthesized a new class of 1,3-thiazolidine-2,4-dione derivatives that exhibit potent activity against several protozoan parasites,...
Investigator(s): Fengtian Xue, Iqbal Hamza
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Parsitology, infection, Immunology
Docket: FX-2015-021
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Novel Ketamine Metabolites for Treating Depression, Anxiety & Addiction
Published Monday, November 7, 2022UMB inventors from Prof. Todd Gould’s lab, along with their collaborators, made the pivotal discovery in 2016 that certain stable ketamine metabolites exerted antidepressant actions via a different mechanism (independent of NMDAR inhibition), which made these compounds excellent drug candidates, without the negative side effects associated with...
Investigator(s): Todd Gould, Jaclyn Highland, Panos Zanos, Craig Thomas, Patrick Morris
Categories: Therapeutics, Small molecules
Keyword(s): small molecule; ketamine-related; depression; addiction
Docket: TG-2021-015
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LRP1 Antagonists for Treatment and Prevention of Alzheimer’s Disease
Published Thursday, May 26, 2022Alzheimer’s disease (AD) is a neurodegenerative disease characterized by gradual deterioration of the brain cells and loss of multiple cognitive functions. The cognitive decline in AD is closely linked to aggregated forms of tau which form neurofibrillary tangles (“NFT”) that initiate in the entorhinal cortex...
Investigator(s): Dudley Strickland, Molly Migliorini, Brian Hampton, Joana Cooper, Selen Muratoglu Catania, Bradley Hyman, Aurelien Lathuiliere
Categories: Therapeutics, Methods of Treatment
Keyword(s): Alzheimer’s Disease, Therapeutics, LRP1, Tau, Method, CNS
Docket: DS-2020-052
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NEU1-Selective Sialidase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis
Published Thursday, May 12, 2022Idiopathic Pulmonary Fibrosis (IPF) is an unrelenting, uniformly fatal disease in which lung architecture is distorted and replaced by scar tissue, thereby compromising pulmonary function. IPF patients only survive 2 to 3 years after diagnosis. Although numerous host factors have been implicated in IPF pathogenesis, no unified mechanistic...
Investigator(s): Simeon Goldblum; Irina Luzina; Sergei Atamas
Categories: Therapeutics, Methods of Treatment
Keyword(s): Fibrosis, Therapeutics, IPF
Docket: SG-2019-090