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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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3D Printed Molds for 3D Tissue Culture Scaffolds
Published Tuesday, November 4, 2014BackgroundCellular and tissue culture is an important aspect of biological research. Having specific cell or tissue types in a controlled environment allows for development and refinement of the efficacy and safety of biological treatments. However, as researchers study more complex conditions, standard monolayer (2D) cell culture is...
Categories: Biological, Research Tools, Antibodies, & Reagents
Keyword(s): PDMS, stem cells, cell culture, tissue culture
Docket: LS-2014-073
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A Rapid Method for Scanning Amino Acid Mutagenesis
Published Tuesday, April 14, 2009In order to study the relationship between structure and function of a protein, the DNA encoding the protein or its corresponding amino acid is subjected to mutations. A number of methods to mutagenize DNA have been developed including site-directed mutagenesis, linker scanning mutagenesis, and the alanine scanning mutagenesis. The first method...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): mutagenisis, mutation, DNA, amino acid, nucleotide, protein
Docket: LS-2007-026
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A stable Receptor-Associated Protein (RAP) protein
Published Tuesday, September 22, 2015A novel Stable Receptor-Associated Protein (RAP), an antagonist of lipoprotein receptor-related protein 1 (LRP1). Dr. Strickland at UMB has developed a stable RAP D3 domain (with 6 mutations) that is resistant to both pH- and heat-induced denaturation. The molecule binds to lipoprotein receptor-related protein 1 (LRP1) with high affinity...
Investigator(s): Dudley Strickland
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): RAP Protein stable
Docket: DS-2015-111
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Anti-GRIM-19 antibody
Published Thursday, May 7, 2015Anti-GRIM-19 (1A8) is a mouse monoclonal antibody for detecting Retinoic-Interferon-induced Mortality 19 (GRIM-19) protein. This antibody was raised against the recombinant human GRIM-19 and can recognize both human and mouse GRIM-19. GRIM-19 is widely expressed in humans, with highest expression in heart, skeletal muscle, liver, kidney...
Investigator(s): Dhan V. Kalvakolanu
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): grim, antibody, tumor suppressor, COPD, carcinoma
Docket: DK-2003-050
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Anti-shark IgNar mouse monoclonal (GA8) antibody
Published Tuesday, September 22, 2015The cartilaginous fish (sharks, skates, and rays) have a human-type adaptive immune system as well as immunoglobulins (Igs). In addition to the heavy-light chain heterodimeric isotypes (IgM and IgW), sharks also produce a novel isotype called IgNAR. IgNAR is a heavy chain homodimer that does not associate with light chains....
Investigator(s): Martin Flajnik
Categories: Research Tools, Antibodies, & Reagents
Docket: MF-2009-077
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Apparatus for Measuring Absolute Complex Conductivity and Surface Impedance of Metals and Superconductors
Published Tuesday, March 9, 1999Knowledge of the skin depth and surface resistance is important for accurate measurements of material conductivity. Knowledge of surface impedance and dielectric properties of materials at microwave frequencies is of increasing importance as the clock rates of computers exceed 1 GHz, the density of magnetic recording media continue to increase,...
Categories: Microelectronics, Research Tools, Antibodies, & Reagents
Keyword(s): skin depth and surface resistance measurements,microwave frequency, thin film
Docket: PS-98-048
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Diagnostic Assay to Study Protein-Nucleic Acid Interactions
Published Tuesday, July 12, 2011BackgroundProtein-nucleic acid interactions including protein-DNA and protein-RNA interactions are crucial to the protection and usage of the genome. There are many methods currently being used to identify and analyze these interactions including filter binding assays, eletrophoretic mobility shift assays (EMSA), Chromatin...
Categories: Research Tools, Antibodies, & Reagents, Platforms, Drug Screen
Keyword(s): Protein-nucleic acid interactions, Protein-DNA interactions, Protein-RNA interactions, High-Throughput, Protein-ligand interactions
Docket: LS-2011-021
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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Fluorescence-Based Assay to Screen for Mitochondrial Protective Compounds
Published Tuesday, May 27, 2014The UMB inventors have developed an enzymatic assay which is a sensitive method for detecting mitochondrial damage. It is based on coupled enzymatic reactions that produce a detectable fluorescence signal in the presence of the reduced or oxidized form of nicotinamide adenine dinucleotide (NADH/NAD) and can detect nanomolar levels of pyridine...
Investigator(s): Tibor Kristian, Gary Fiskum
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: TK-2004-007
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High Affinity Aptamer for Detection of HIV Reverse Transcriptase
Published Tuesday, June 3, 2014BackgroundThe development of multi-drug therapy for HIV has greatly extended the lives of patients undergoing multi-drug therapy. For best results, multi-drug therapy requires early detection and constant monitoring of viral loads in patients. Current technologies for viral load monitoring require dedicated machinery and highly skilled...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): HIV diagnostic, point-of-care
Docket: LS-2014-032