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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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A Method for Monitoring Cancer and for Regulation of Semaphorin 4D to Improve Cancer Immunotherapy Regimens
Published Monday, May 14, 2018The efficacy of current cancer immunotherapies has been limited by the response of immunosuppressive elements such as myeloid derived suppressor cells (MDSC) and T regulatory cells. Understanding the mechanism behind the suppression of antitumor immunity, and finding ways to revert it, should lead to improved cancer immunotherapy outcomes....
Investigator(s): Rania Younis
Categories: Diagnostics, Biomarker, Therapeutics
Keyword(s): Semaphorin 4D, immunotherapy, oncology, head and neck, cancer
Docket: RY-2015-129
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A Method of Machine Transliteration between Different Writing Systems
Published Monday, April 9, 2018BackgroundWriting system is a set of characters and the corresponding rules used to represent a language. Characters could be either graphemes (letters) or phonemes (characters representing a phonetic sound). The process of writing system conversion transforms one system into another using mapping rules. This could be accomplished either...
Categories: Information Technology
Keyword(s): 525
Docket: IS-2013-109
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A Method of Matrix Spectral Factorization
Published Sunday, June 29, 2014BackgroundSpectral factorization is a method of reducing a matrix of a high order dimension into a series of smaller matrices to perform more efficient computations. Spectral factorization has broad applications, including signal and image filtering, control systems, data processing, and data compression. However, spectral factorization...
Categories: Software + Algorithm
Keyword(s): signal processing, matrices, data compression
Docket: IS-2008-049
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A Microbial Biosensor for Ethylene Gas
Published Monday, May 27, 2013BackgroundEthylene is a gas that serves as a hormone in plants and is critical for many aspects of plant growth and development such as stimulating or regulating the ripening of fruit, the opening of flowers, and the shedding of leaves. Environmental cues such as flooding, drought, chilling, wounding, and pathogen attack can induce...
Categories: Sensors/Monitors
Keyword(s): ethylene, gas, ethylene gas, gas detection, ethylene detection, detection, hormone, biosensor, sensor, ethylene receptor, receptor
Docket: LS-2012-090
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A Microdevice for the Enrichment of Tumor-Initiating Breast Cancer Stem Cells
Published Wednesday, October 3, 2012BackgroundDespite the numerous advances in cancer treatment, there is frequent relapse and metastasis of cancer. The cancer stem cell hypothesis argues that a small minority of cancer stem cells (CSCs) in a heterogeneous tumor population drives the tumor growth and has drug resistant properties. One of the techniques in isolation and...
Keyword(s): 525
Docket: PS-2012-092
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A Nanomaterial Platform For Auto-immune Disease Therapy
Published Wednesday, April 12, 2017BackgroundThe immune system protects the body from foreign pathogens. However, errors in the immune system can cause attacks on and elimination of the body’s own cells - called autoimmune reactions - the primary cause behind multiple sclerosis, rheumatoid arthritis, certain types of allergies, and asthma. Such reactions are also relevant...
Keyword(s): autoimmune disease, Multiple Sclerosis, therapy, Therapeutic
Docket: LS-2016-175
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A New Approach to Contacting Nanowire Arrays Using Nanoparticles
Published Wednesday, April 18, 2007Despite significant advancements in nanowire growth techniques and device descriptions, establishment of electrical contacts to nanowire assemblies through non-destructive methods has not yet been successfully realized. The commonly employed method involves physically removing nanowires through some form of lithography. Such a series of steps are...
Categories: Nanotechnology + Nanoparticles + Nanomaterials, Microelectronics
Keyword(s): Nanowires, 525
Docket: PS-2007-031
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A New Biochemical Route to Astaxanthin
Published Monday, November 27, 2006Astaxanthin, a caroteniod compound, has found use as a topical antioxidant and as an ingredient for human nutritional supplements.Currently synthetic astaxanthin is added to feeds prepared for production of salmonids and red sea bream in aquaculture to provide a source of this carotenoid compound. There is an increasing demand...
Categories: Natural Compounds
Keyword(s): nutrition, astaxanthin, carotenoid, pigment
Docket: LS-2005-054
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A New Type of Perfluorocarbon Based Nanofluids for Effective Heat Transfer
Published Wednesday, January 18, 2006Thermal management in the next decade of microelectronics and optoelectronics will require heat transfer fluids with improved performance over those currently available. Nanofluids exhibit significant enhancement in thermal conductivity but are not practical because of low long-term stability issues and an inability to currently mass-produce such...
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): FC-72, perfluro, working fluid, nano, cooling, evaporation
Docket: PS-2005-091
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A Non-Intrusive Pressure-Line Dryer
Published Wednesday, October 3, 2012Although it is straightforward to use desiccant to dry the air that is confined inside a small container, it becomes challenging when the air pressure also needs to be constant and monitored. If a desiccant holder is attached to the system, then the total volume of the system is changed, which will impact the pressure measurement. In addition,...
Categories: Industrial Processing
Keyword(s): desiccant, humidity, Pressure-Line Dryer
Docket: PS-2012-025