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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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An Easy-to-Deploy Temporal Thermographic Data Collection and Analysis System
Published Thursday, May 3, 2018Buildings in the United States consume a significant amount of energy and release an increasing amount of CO2. Accordingly, tools and techniques have been developed to determine where energy efficiency in buildings can be improved. One such technique is thermography, where auditors determine energy inefficiency using a thermal camera that shows...
Categories: Software + Algorithm, Information Technology
Keyword(s): temporal, thermography, visualization, energy, efficiency
Docket: PS-2017-069
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An Encapsulated Electrode for EHD Application
Published Tuesday, March 9, 1999The Electrohydrodynamic (EHD) technique is a new and promising technique which has proven potential for pumping in the absence of any moving mechanical parts. Also, the EHD effect has demonstrated significantly enhanced heat transfer. The combination of these two capabilities makes the use of the EHD a viable emerging technology for high-...
Categories: Microelectronics
Keyword(s): electrohydrodynamic, EHD, pumping, moving parts, heat transfer
Docket: PS-98-045
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An Improved Avian Influenza Vaccine for New Born Chicks
Published Sunday, July 8, 2018Background Avian influenza Virus (AIV) outbreaks not only cause the decimation of broiler and egg-laying chicken populations at once but also result a close to 50% increase in the price of poultry meat and eggs, thereby impacting the end consumer as well. Currently, effective vaccines against AIV are not available. AIV outbreaks are...
Keyword(s): 525
Docket: LS-2017-075
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An Interferon Enhancer for Enhancement of Immune Response for Vaccine Applications
Published Wednesday, October 31, 2012BackgroundInterferons (IFNs) are a group of cytokines or proteins that are made and released by host cells in response to infections by viruses and bacteria. IFNs allow for host cells to communicate with each other and hence trigger a strong immune response. There are three types of IFNs that have similar functions of being antiviral and...
Categories: Vaccines, Biologics
Keyword(s): Interferon, IFN, viral, viral infection, bacterial, bacterial infection, infection, virus, bacteria, immune system, immune, immune response, pathogen, vaccine, cytokine
Docket: LS-2012-081
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Analogs of GHB Lacking GABAergic Activity
Published Monday, February 11, 2019The present invention relates to esthers of 3-hydroxyphenyacetic acid and their use to treat narcolepsy and other sleep disorders. Gamma-hydroxybutyric acid (GHB) is a known agonist for the GHB receptor. Unfortunately it also acts at GABA receptors directly and through its metabolization into alpha aminobutyric acid (GABA). As a result,...
Investigator(s): Andrew Coop, Maharaj Ticku, Charles France
Categories: Therapeutics, Small molecules
Keyword(s): narcolepsy, cataplexy, sleep disorderes
Docket: AC-2006-050
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Analyte Sensor Device and miniaturized Gel Holders, Methods and Systems Utilizing the Same
Published Tuesday, May 27, 2014Bioavailable metal ions (e.g. Cu2+, Zn2+) are essential nutrient required for the normal, healthy growth of plants, animals, and humans. Careful monitoring of these ions is often deployed to gauge levels within the environment to ensure safety as well as functionally adequate concentrations for economical utility. To quickly and easily monitor...
Investigator(s): Richard Thompson
Categories: Devices
Docket: RT-2007-027
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ANALYTE-SENSITIVE PROBES AND CONTACT LENS FOR DIAGNOSIS OF OCULAR PATHOLOGIES
Published Thursday, November 9, 2023Summary The patent introduces a contact lens integrated with analyte-sensitive probes for diagnosing ocular pathologies through the detection of specific analytes in basal tears. This non-invasive, real-time monitoring technology has applications in medical diagnostics and...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Imaging devices, Diagnostics, Imaging, Healthcare
Keyword(s): Analyte-sensitive probes, fluorescence, Diagnostics, Real-time monitoring
Docket: JL-2019-091
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Anisotropic Electroconductive Adhesive Film
Published Wednesday, May 13, 2009With the advent of the multimedia society, the development is progressing on a variety of electronic devices capable of quickly and easily retrieving, processing and transmitting large quantities of information, such as video information. These devices require high-density packaging, weight reductions and cost reductions. As a packaging method...
Categories: Nanotechnology + Nanoparticles + Nanomaterials, Chemical
Keyword(s): electroconductive adhesive film nanowire
Docket: PS-2006-086
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Anthrax toxin protective antigen proteins engineered to target membrane-anchored serine proteases overexpressed on tumor cells
Published Friday, January 26, 2018Bacillus anthracis is the bacterium that produces the anthrax toxin, which consists of the three distinct proteins protective antigen (PrAg), lethal factor (LF), and edema factor (EF). In order for the toxin to be activated, the PrAg moiety of the toxin must bind to cell-surface proteins and become proteolytically cleaved by the proprotein...
Investigator(s): Toni Antalis, Erik Martin
Categories: Therapeutics, Biologics
Keyword(s): oncology, protein therapy, anthraz, ZMT
Docket: TA-2016-015
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Anti-GRIM-19 antibody
Published Thursday, May 7, 2015Anti-GRIM-19 (1A8) is a mouse monoclonal antibody for detecting Retinoic-Interferon-induced Mortality 19 (GRIM-19) protein. This antibody was raised against the recombinant human GRIM-19 and can recognize both human and mouse GRIM-19. GRIM-19 is widely expressed in humans, with highest expression in heart, skeletal muscle, liver, kidney...
Investigator(s): Dhan V. Kalvakolanu
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): grim, antibody, tumor suppressor, COPD, carcinoma
Docket: DK-2003-050