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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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A Novel Vector to Assay Translational Recoding
Published Tuesday, April 11, 2017Background Translational recoding is a mechanism typically employed by viruses to achieve efficient production of proteins required for assembly and replication. Operationally, translational recoding employs unique 3-dimensional RNA structures that drive ribosomes to slip “out of frame” (Programmed Ribosomal Frameshifting) or to bypass stop...
Keyword(s): ribosomal frameshifting, trasnlational recoding, efficiency monitoring, reporter vector, Fluorescence, quantitative measurement
Docket: LS-2016-091
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Tick Protein as Vaccine Candidate for Tick-borne Lyme Disease Pathogen
Published Tuesday, April 11, 2017Background: Lyme disease is a vector-borne disease caused by spirochaete Borrelia burgdorferi. By the 2014 Center for Disease Control (CDC) estimates, incidence of Lyme disease has grown in the US from ~11,000 cases reported in 1995 to over 30,000 cases in 2014. Additional literature from NIH places the number of new cases at 300,000 annually...
Keyword(s): Lyme Disease, vaccine
Docket: LS-2016-010
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Targeting plant hormone metabolism to promote growth and development in deficient conditions
Published Tuesday, April 11, 2017Background: Auxins are plant growth hormones that play a crucial role in developmental processes that include gametogenesis, embryogenesis, seedling growth, vascular patterning, and floral development. Understanding biodegradation of auxins will help uncover novel targets to spatio-temporally modulate the hormone levels thereby...
Keyword(s): plant growth, high yields, seed size, plant size, rooting, delayed bud opening, 525
Docket: LS-2016-014
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Cyber Disruption Index and Framework
Published Tuesday, December 20, 2016BackgroundCurrently, there is no method of measuring and categorizing cyber threats and disruptions. As a result policy makers are unable to push for reforms that would adequately address the malicious cyber activity. Organizations have had difficulty dealing with these types of threats. Innovative TechnologyResearchers at...
Keyword(s): 525
Docket: IS-2016-083
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Simetric
Published Monday, December 19, 2016BackgroundChildren undergoing medical procedures experience stressful reactions that can impair treatment and recovery. Currently, hospitals employ various methods to reassure these children, including showing them the treatment room and talking them through the procedure. However, some hospitals lack the necessary resources to accomplish...
Categories: Software + Algorithm, Engineering
Keyword(s): virtual reality, procedure, stress, anxiety, treatment
Docket: IS-2016-073
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Health and Disease Monitoring in the Heart and the Aorta based on Model-Based Ballistocardiogram Analysis
Published Thursday, November 17, 2016Background: Ballistocardiogram (BCG) is a direct consequence of how the heart ejects blood, thus its waveform can have a lot to do with the cardiac function. Many efforts have been made to mathematically relate the abnormalities in the BCG waveform to heart disease. However, the existing technologies only qualitatively explain the coupling...
Keyword(s): 525
Docket: IS-2015-163
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A Counterfeit Detection Scheme using Paper Surfaces and Mobile Cameras
Published Tuesday, August 23, 2016BackgroundCounterfeiting is a world-wide problem affecting high value documents, high end consumer product labels, and other assets. Traditional anti-counterfeiting mechanisms heavily rely on visual examination of the document or product label and decision of a particular examiner. Recent technological solutions include optically capturing...
Keyword(s): counerfeit, document, paper, authentication, mobile platform, security
Docket: IS-2015-165
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Multi-Sensor Aerosol Products Sampling System (MAPSS)
Published Monday, August 22, 2016Global and local properties of atmospheric aerosols have been extensively observed and measured using both spaceborne and ground-based instruments, especially during the last decade. Unique properties retrieved by the different instruments contribute to an unprecedented availability of the most complete set of complimentary aerosol measurements...
Keyword(s): atmosphere; climate; aerosols; atmospheric aerosols
Docket: IS-2016-118
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HyperCubeMap: Optimal Social Network Ad Allocation Using Hyperbolic Embedding
Published Sunday, August 21, 2016BackgroundSocial networking sites (SNS) such as Facebook, Twitter, and others have increasingly become a popular advertising platform for marketers. Advertisers bid for a target group of users’ action, most often for the number of impressions, and pay using per-per-mille billing policy (per one thousand impressions). The problem arises when...
Keyword(s): 525
Docket: IS-2016-072
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EventAction
Published Sunday, August 21, 2016EventAction is a prescriptive analytics interface designed to present and explain recommendations of temporal event sequences. EventAction provides a visual analytics approach to (1) identify similar records, (2) explore potential outcomes, (3) review recommended temporal event sequences that might help achieve the users’ goals, and (4)...
Keyword(s): Data visualization, event, temporal sequence, consumer behavior, coaching, medical treatment, academic advising
Docket: IS-2016-062