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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Analogs of GHB Lacking GABAergic Activity
Published Monday, February 11, 2019The present invention relates to esthers of 3-hydroxyphenyacetic acid and their use to treat narcolepsy and other sleep disorders. Gamma-hydroxybutyric acid (GHB) is a known agonist for the GHB receptor. Unfortunately it also acts at GABA receptors directly and through its metabolization into alpha aminobutyric acid (GABA). As a result,...
Investigator(s): Andrew Coop, Maharaj Ticku, Charles France
Categories: Therapeutics, Small molecules
Keyword(s): narcolepsy, cataplexy, sleep disorderes
Docket: AC-2006-050
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Noninvasive Characterization of Mechanical Properties of Materials and Tissue using Magnetic Resonance Techniques
Published Wednesday, February 6, 2019Many diseases alter the mechanical properties of tissue. Accordingly, the mechanical properties can serve as biomarkers for disease, diagnosis, and tumor assessment. While some larger diseased tissues or abnormalities near the surface of a patient can be detected by palpitation, many are located deep within the patient or too small to...
Investigator(s): Bruce Yu, Mark Taraban, Yue Feng
Categories: Devices, Software + Algorithm, Sensors/Monitors, Industrial Processing, Other
Keyword(s): MRI, NMR, diagnostic
Docket: BY-2012-013
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Bidirectional Flow Cannula
Published Thursday, January 31, 2019In order to accommodate the high blood flows in veno-arterial extracorporeal membrane circulation (VA ECMO) and cardiopulmonary bypass (CPB), large cannulae are inserted into a patient’s femoral vein, to drain blood to the system, and into the femoral artery to...
Investigator(s): Bartley Griffith, Zachary Kon, Chetan Pasrija, Mehrdad Ghoreishi, Gregory Bittle
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiopulmonary, Life-support, ECMO
Docket: ZK-2017-057
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MITRAL VALVE TRANSLOCATION DEVICE AND METHOD FOR THE TREATMENT OF FUNCTIONAL MITRAL REGURGITATION
Published Thursday, January 31, 2019There is currently no reliable, durable mitral valve repair option for patients with Functional Mitral Regurgitation (FMR). Replacing the mitral valve with a prosthetic tissue or mechanical valve is currently the most durable approach to the treating FMR. However, this procedure has a high perioperative mortality risk and carries the risk...
Investigator(s): James Gammie
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiology, Mitral regurgitation
Docket: JG-2017-025
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Magnetic nanoparticles in dentistry
Published Thursday, January 24, 2019University of Maryland clinical researchers saw a clear need to target therapeutic agents to dental tissues with a method that would avoid the need for an invasive procedure like a root canal. Drs. Masri and Depireux devised a platform strategy to actively deliver therapeutic payloads to the inner tooth, which relies on magnetic nanoparticles...
Investigator(s): Radi Masri, Didier Depireux
Categories: Devices, Medical implants, Drug delivery devices, Platforms, Materials, Dental
Docket: RM-2014-062
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Monoclonal antibodies inhibiting fibrin-VLDL receptor-dependent inflammation
Published Tuesday, January 22, 2019Fibrin is a fibrous, non-globular protein involved in blood clotting and promotes leukocyte transmigration through its interaction with the endothelial cell receptor, the very low density lipoprotein (VLDL) receptor. The VLDL receptor is predominantly expressed in the heart, skeletal muscle, fat, brain and macrophages and involved in neural...
Investigator(s): Leonid Medved, Sergiy Yakovlev, Dudley Strickland
Categories: Therapeutics, Biologics
Keyword(s): Cardiology, antibody, inflammation, fibrin
Docket: LM-2016-049
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Modulation of the Microtubule-Dependent Mechanotransduction as a Therapeutic Intervention in Osteoporosis
Published Thursday, June 28, 2018Bones become thinner and weaker as a consequence of aging. By their mid-30s most individuals have greater bone resorption (bone mass loss) compared to bone formation. Osteoporosis is the result of this loss of bone mass and subsequent changes in bone structure, contributing to skeletal fragility and increased propensity of fractures. Osteocytes...
Investigator(s): Joseph P. Stains, James S. Lyons, Christopher W. Ward
Categories: Methods of Treatment
Keyword(s): Musculoskeletal disorder, bone, osteoporosis
Docket: JS-2017-008
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Inverted Culture Plate Insert for Cellular Co-Culture
Published Wednesday, June 27, 2018Lack of metabolic competence is a major limitation for the majority of current high throughput screening (HTS) assays used for screening drugs, environmental chemicals and industrial compounds for toxicity. As many compounds are metabolically transformed in vivo, toxicity assays should reflect physiologically-relevant metabolism to accurately...
Investigator(s): Bryan Mackowiak, Hongbing Wang, Linhao Li
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: BM-2017-002
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Selective RARγ Ligand-loaded Nanoparticles for Manipulation of Targeted Bone Growth
Published Wednesday, June 27, 2018Imbalance in bone length, caused by congenital conditions or fractures, can result in progressive deformity and physical problems. To date, the only way to adjust these bone length problems are surgical procedures. UMB researchers have identified a nuclear retinoid receptor, RARγ, which controls the rate of transition from cartilage to...
Investigator(s): Masahiro Iwamoto, Michael Chorny
Categories: Therapeutics, Other
Keyword(s): Orthopedics, Therapeutics Drug Delivery System
Docket: MI-2017-124
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Liquid Biopsy Test for Early Detection of Lung Cancer
Published Wednesday, May 23, 2018Low-dose computed tomography (LDCT) is recommended for annual screening by the US Preventive Services Task Force, and the test is reimbursed by Medicare (see below). LDCT is intended for early detection of cancer, but unfortunately has a high false-positive rate (i.e., it detects indeterminate pulmonary nodules (PNs), 96% of...
Investigator(s): Feng Jiang
Categories: Diagnostics
Keyword(s): oncology, Diagnostics
Docket: FJ-2016-076, FJ-2017-097