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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Bacterial Strains and imp Mutations that Result in Altered Cellular Permeability
Published Tuesday, April 30, 1996Bacteria are a major cause of contamination in food and water-borne diseases. To eliminate and treat bacterial infections many drugs are formulated and synthesized. Chemicals synthesized as potential anti microbial compounds and/or therapeutic drugs need to be tested for their efficacy. To do this, a good screening system with a test bacteria is...
Categories: Drug Screen
Keyword(s): Bacterial strains (1BIO020), Anti-infective drugs (1MED090)
Docket: LS-95-055
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An E. coli Strain, BAS2006, that Carries Mutations that Confer Increased Permeability
Published Tuesday, March 9, 1999Bacteria are a major cause of contamination in food and water-borne diseases. To eliminate and treat bacterial infections many drugs are formulated and synthesized. Chemicals synthesized as potential anti microbial compounds and/or therapeutic drugs need to be tested for their efficacy. To do this, a good screening system with a test bacteria is...
Categories: Drug Screen
Keyword(s): Bacterial Strains and Cultures (1BIO020), Drug Discovery
Docket: LS-97-076
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Defined Mutations in the E. coli Porins Genes impF and impC that Confer Increased Permeability
Published Tuesday, March 9, 1999Bacteria are a major cause of contamination in food and water-borne diseases. To eliminate and treat bacterial infections many drugs are formulated and synthesized. Chemicals synthesized as potential anti microbial compounds and/or therapeutic drugs need to be tested for their efficacy. To do this, a good screening system with a test bacteria is...
Categories: Drug Screen
Keyword(s): Bacterial Strains and Cultures (1BIO020), Drug Discovery
Docket: LS-97-077
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Eukaryotic Heme Transport as a Drug Target for Helminthic Infections
Published Sunday, November 12, 2006Helminthic infestations by parasitic worms afflict more than two billion people worldwide and cause more than eighty billion dollars of annual crop-loss globally. Novel treatments for these parasitic infections, for which there is no universal cure, can be developed based on studies by a University of Maryland researcher on heme transport using...
Categories: Natural Compounds, Drug Screen
Keyword(s): heme, heme synthesis, iron deficiency, anemia, parasite, parasitic infections
Docket: LS-2004-002
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Control of Apoptosis by Controlling the Propensity of Ceramide Channel Formation
Published Wednesday, July 27, 2005Cell researchers believe that the efflux of proteins from mitochondria is an activation event that eventually leads to apoptosis.A number of mechanisms have been proposed for the protein permeation pathway. Candidate mechanisms include the ceramide channels. Researchers at the University of Maryland have a fairly robust model...
Categories: Chemicals, Drug Screen
Keyword(s): ion channels, apoptosis, ceramide
Docket: LS-2005-049
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Universal High-Throughput Detection of Protein-Ligand Interactions
Published Monday, October 11, 2010BackgroundThe knowledge of protein-ligand and protein-metabolite interactions has significant implications in modern drug design and use. Since each of these molecular interactions represents a potential pharmaceutical intervention in disease and agriculture, there is an urgent need to collect qualitative and quantitative functional...
Categories: Research Tools, Antibodies, & Reagents, Drug Screen, Platforms
Keyword(s): Protein-Ligand Interaction, Diagnostic Kit to study Protein Ligand Interaction, Diagnostic kit, Biomolecular Interactions
Docket: LS-2010-086
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Diagnostic Assay to Study Protein-Nucleic Acid Interactions
Published Tuesday, July 12, 2011BackgroundProtein-nucleic acid interactions including protein-DNA and protein-RNA interactions are crucial to the protection and usage of the genome. There are many methods currently being used to identify and analyze these interactions including filter binding assays, eletrophoretic mobility shift assays (EMSA), Chromatin...
Categories: Research Tools, Antibodies, & Reagents, Platforms, Drug Screen
Keyword(s): Protein-nucleic acid interactions, Protein-DNA interactions, Protein-RNA interactions, High-Throughput, Protein-ligand interactions
Docket: LS-2011-021