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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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NEU1-Selective Sialidase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis
Published Thursday, May 12, 2022Idiopathic Pulmonary Fibrosis (IPF) is an unrelenting, uniformly fatal disease in which lung architecture is distorted and replaced by scar tissue, thereby compromising pulmonary function. IPF patients only survive 2 to 3 years after diagnosis. Although numerous host factors have been implicated in IPF pathogenesis, no unified mechanistic...
Investigator(s): Simeon Goldblum; Irina Luzina; Sergei Atamas
Categories: Therapeutics, Methods of Treatment
Keyword(s): Fibrosis, Therapeutics, IPF
Docket: SG-2019-090
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Method to Preserve Post-radiotherapy Ventilation by Mitigating Radiation-Induced Airway Injury
Published Tuesday, September 7, 2021Preserving post-radiotherapy respiratory function is an important consideration in thoracic radiation therapy. A common limitation of current clinical and investigational approaches that attempt to achieve this objective is that they ignore radiation injury to the elements of the bronchial tree, which are critical to the gas exchange...
Investigator(s): Amit Sawant; Esther Vicente; Arezoo Modiri; Robert Timmerman; Yulong Yan; Henky Wibowo
Categories: Imaging, Healthcare, Methods of Treatment
Keyword(s): Radiation Treatment Planning; Software; Imaging; Oncology; Cancer
Docket: AS-2019-095
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System and Method for Diagnosis, Monitoring, and Treatment of Obstructive Sleep Apnea
Published Monday, September 30, 2019Sleep Apnea treatment represents a $6 billion market in the United States. Current treatment methods suffer from poor compliance rates. The inventors have proposed a novel ultrasound device to diagnose and treat sleep apnea.
Investigator(s): Amal Isaiah, Jeffrey Wolf
Categories: Devices, Imaging devices, Diagnostics, Imaging, Methods of Treatment
Keyword(s): sleep apnea
Docket: AI-2018-039
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Bidirectional Flow Cannula
Published Thursday, January 31, 2019In order to accommodate the high blood flows in veno-arterial extracorporeal membrane circulation (VA ECMO) and cardiopulmonary bypass (CPB), large cannulae are inserted into a patient’s femoral vein, to drain blood to the system, and into the femoral artery to...
Investigator(s): Bartley Griffith, Zachary Kon, Chetan Pasrija, Mehrdad Ghoreishi, Gregory Bittle
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiopulmonary, Life-support, ECMO
Docket: ZK-2017-057
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MITRAL VALVE TRANSLOCATION DEVICE AND METHOD FOR THE TREATMENT OF FUNCTIONAL MITRAL REGURGITATION
Published Thursday, January 31, 2019There is currently no reliable, durable mitral valve repair option for patients with Functional Mitral Regurgitation (FMR). Replacing the mitral valve with a prosthetic tissue or mechanical valve is currently the most durable approach to the treating FMR. However, this procedure has a high perioperative mortality risk and carries the risk...
Investigator(s): James Gammie
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiology, Mitral regurgitation
Docket: JG-2017-025
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Modulation of the Microtubule-Dependent Mechanotransduction as a Therapeutic Intervention in Osteoporosis
Published Thursday, June 28, 2018Bones become thinner and weaker as a consequence of aging. By their mid-30s most individuals have greater bone resorption (bone mass loss) compared to bone formation. Osteoporosis is the result of this loss of bone mass and subsequent changes in bone structure, contributing to skeletal fragility and increased propensity of fractures. Osteocytes...
Investigator(s): Joseph P. Stains, James S. Lyons, Christopher W. Ward
Categories: Methods of Treatment
Keyword(s): Musculoskeletal disorder, bone, osteoporosis
Docket: JS-2017-008
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Dichloroacetate and Arsenic Trioxide as an Acute Myeloid Leukemia Combination Therapy
Published Tuesday, May 16, 2017UMB research has been directed at a synergistic combination drug formulation of dichloroacetate and arsenic trioxide to treat AML. AML cells, compared to normal cells, have an increased susceptibility to the disruption of balance of oxidative forces. Selective targeting of the oxidative state, which is a tightly balanced...
Investigator(s): Ashkan Emadi, MD; Rena Lapidus, PhD
Categories: Repurpose Drug, Methods of Treatment
Keyword(s): AML; Acute Myeloid Leukemia; Combination Therapy; Arsenic Trioxide
Docket: AE-2013-045
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Balanced Reach Control Systems Model
Published Tuesday, May 2, 2017Bipedal standing balance is inherently unstable and must be actively controlled to prevent falling. This involves a complex interaction of the sensorimotor system and multi-segment musculoskeletal system. Fall risk increases with deterioration of sensorimotor and musculoskeletal elements responsible for balance due to age, neurological...
Investigator(s): Joseph E. Barton
Categories: Devices, Imaging devices, Software + Algorithm, Methods of Treatment
Keyword(s): Rehabilitation, balance, reaching, Aging Population
Docket: JB-2016-005, JB-2016-004
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Surrogate-Based Prediction Model for Real-Time Tumor Monitoring during Radiotherapy
Published Friday, March 31, 2017To ensure tumor-targeting accuracy over the course of radiation treatment while minimizing the dosimetric impact to healthy tissue, respiratory surrogate models are utilized to monitor tumor position while compensating for tumor motion. These models are developed from a training dataset of concurrent tumor positions and...
Investigator(s): Warren D’Souza PhD
Categories: Software + Algorithm, Healthcare, Methods of Treatment
Keyword(s): radiology; medical imaging; image-guided radiation therapy
Docket: WD-2010-069
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Correction of Ischemia with p53 Inhibitors: A Novel Therapeutic Approach to Induce Arteriogenesis
Published Friday, February 24, 2017Severe obstruction of the arteries and reduced blood flow (critical limb ischemia(CLI)) is the advanced stage of peripheral artery disease (PAD). Investigators at UMB have found that Pifithrin-α, a p53 pharmacological inhibitor, improves limb perfusion in diabetic animals, suggesting a therapeutic role in CLI. Tumor-suppressing...
Investigator(s): Rajabrata Sarkar, Mark Hoofnagle, Subhradip Mukhopadhyay
Categories: Therapeutics, Methods of Treatment
Keyword(s): cardiovascular
Docket: RS-2013-040