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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Identification of Toll-Like Receptor 2 (TLR2) Antagonists Using Computer-Aided Drug Design
Published Wednesday, March 6, 2024Toll-like receptors (TLR) are innate immune molecules involved in the detection of microbial and self-ligands released from damaged cells. At their C-termini, toll/interleukin-1 receptor (TIR) domains dimerize upon ligand binding, initiating a signaling cascade that results in the upregulation of inflammatory cytokines. Excessive signaling can...
Investigator(s): Alexander D. MacKerell, Stefanie N. Vogel
Categories: Platforms, Therapeutics
Keyword(s): TLR2, sepsis, anti-inflammation, TIR
Docket: SV-2010-075
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Magnetic nanoparticles in dentistry
Published Thursday, January 24, 2019University of Maryland clinical researchers saw a clear need to target therapeutic agents to dental tissues with a method that would avoid the need for an invasive procedure like a root canal. Drs. Masri and Depireux devised a platform strategy to actively deliver therapeutic payloads to the inner tooth, which relies on magnetic nanoparticles...
Investigator(s): Radi Masri, Didier Depireux
Categories: Devices, Medical implants, Drug delivery devices, Platforms, Materials, Dental
Docket: RM-2014-062
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Portable Multi-Parameter Cancer Diagnostic Device
Published Sunday, May 17, 2015Background: Each year in USA alone, more than 200,000 breast cancer cases are diagnosed. The transformation from benign to cancerous state changes the morphological signatures in the tumor environment. Mechanical and electrical phenotyping has been demonstrated as a promising technique to study the progression of the breast cancer. Thus, a...
Categories: Diagnostics, Platforms, Devices
Keyword(s): breast cancer, Cancer Diagnosis
Docket: PS-2015-017
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Immunotherapeutic Potential of Modified Lipooligosaccharides/Lipid A: A Platform for “Custom-designed Adjuvants”
Published Wednesday, November 12, 2014Lipid A, the hydrophobic anchor of lipopolysaccharide (LPS), can stimulate the innate immune system via Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2), leading to the release of inflammatory cytokines/chemokines and type I interferons. In turn, this response increases the host’s ability to eradicate a pathogen and supports...
Investigator(s): Robert K Ernst, Adeline Hajjar, Mark Pelletier
Categories: Platforms, Biologics, Vaccines, Biological, Vaccine, Other
Keyword(s): adjuvant, subunit vaccine, lipid A, platform, lipopolysaccharide, immunostimulation custom synthesis
Docket: RE-2012-067
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An Automated Medical Student Performance Evaluation Software
Published Friday, September 26, 2014In the United States and Canada, a Medical Student Performance Evaluation (MSPE) is required as part of a medical student’s residency application. The MSPE includes specific information from the student’s academic record including both didactic and clinical courses. The Automated Student Affairs Processes (ASAP) is a user-friendly, platform...
Investigator(s): Kevin Brown, Priyanka Koneru, Sara Menso
Categories: Platforms, Software + Algorithm, Information Technology, Education/Training/Multimedia
Keyword(s): MSPE, software, medical school, administrative office, medical admissions
Docket: KB-2014-002
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TLR Inhibitors for Treatment of Influenza, Cancer, Allergy, Inflammation and Prevention of Endotoxic Shock
Published Wednesday, May 28, 2014The Toll-like receptors (TLRs) play a vital role in eradicating pathogenic microbial infections, eliminating necrotic host cells and enhancing tissue repair in the host. On the flip side, chronic TLR activation leads to inflammatory disease and “systemic” activation of TLRs may lead to death. ...
Investigator(s): Vladimir Toshchakov
Categories: Research Tools, Antibodies, & Reagents, Platforms, Therapeutics, Biologics
Keyword(s): TLR, decoy peptides, inflammation, cancer, microbial infections, immune disorders, allergy, endotoxic shock, TRAM, TRIF, TIRAP and MyD88
Docket: VT-2012-029 VT-2012-052
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High affinity recombinant sea lamprey antibodies selected by a yeast surface display platform.
Published Tuesday, May 27, 2014Immunoglobulin-based antibody therapeutics are enjoying unprecedented success. Hundreds are in clinical trials, with revenues from the top five (Rituxan, Remicade, Herceptin, Humira, and Avastin) increasing from $6.4 billion in 2004 to $11.7 billion in 2006 (Dimitrov & Marks, 2009). Thousands more are available for biological detection...
Investigator(s): Zeev Pancer, Roy Mariuzza, Satoshi Tasumi, Carlos Velikousky
Categories: Diagnostics, Platforms
Docket: ZP-2010-085
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Diagnostic Assay to Study Protein-Nucleic Acid Interactions
Published Tuesday, July 12, 2011BackgroundProtein-nucleic acid interactions including protein-DNA and protein-RNA interactions are crucial to the protection and usage of the genome. There are many methods currently being used to identify and analyze these interactions including filter binding assays, eletrophoretic mobility shift assays (EMSA), Chromatin...
Categories: Research Tools, Antibodies, & Reagents, Platforms, Drug Screen
Keyword(s): Protein-nucleic acid interactions, Protein-DNA interactions, Protein-RNA interactions, High-Throughput, Protein-ligand interactions
Docket: LS-2011-021
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Universal High-Throughput Detection of Protein-Ligand Interactions
Published Monday, October 11, 2010BackgroundThe knowledge of protein-ligand and protein-metabolite interactions has significant implications in modern drug design and use. Since each of these molecular interactions represents a potential pharmaceutical intervention in disease and agriculture, there is an urgent need to collect qualitative and quantitative functional...
Categories: Research Tools, Antibodies, & Reagents, Drug Screen, Platforms
Keyword(s): Protein-Ligand Interaction, Diagnostic Kit to study Protein Ligand Interaction, Diagnostic kit, Biomolecular Interactions
Docket: LS-2010-086