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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Profiles of Individual Radicalization in the United States (PIRUS)
Published Wednesday, February 28, 2018PIRUS is a dataset of individuals in the United States who radicalized to the point of violent or non-violent ideologically motivated criminal activity, or ideologically motivated association with a foreign or domestic extremist organization from 1948 to 2013 (and two cases in 2014). The PIRUS dataset was coded using entirely open-source material...
Categories: Genomics/Proteomics/Database
Keyword(s): 525
Docket: IS-2017-020
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MakerWear
Published Wednesday, February 28, 2018Wearable construction kits have shown promise in attracting underrepresented groups to STEAM (Science, Technology, Engineering, Art and Math). They empower users to create self-expressive and personally meaningful designs while fostering an interest in computing. However, these kits require skills that young children (K-6) do not possess:...
Categories: Software + Algorithm, Engineering, Devices, Sensors/Monitors
Keyword(s): wearable, construction kit, modular,
Docket: IS-2017-018
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A Repurposed Use for an FDA Approved Drug to Combat Tuberculosis and Gut Pathogens
Published Monday, February 26, 2018Background As of 2015, the World Health Organization (WHO) estimates there are about 10.4 million people who fell ill due to tuberculosis (TB). Current treatment course includes a multiple-drug regimen for 2 months followed by a 4 month course with fewer medicines. The emergence of drug resistant strains of the bacterium due to longer...
Keyword(s): 525
Docket: LS-2017-038
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A Novel Method or Colloidal Gel Preparation Useful for Surgical Embolization
Published Monday, February 26, 2018Background Colloidal gels- mixture of two or more substances that neither dissolve nor settle down in solution- can be generated by mixing two or more substances together that can form intricate mesh-like networks. These networks are sustained through various chemical interactions such as hydrogen bonds, electrostatic interactions or...
Categories: Drug delivery devices, Biomaterials
Keyword(s): 525
Docket: LS-2017-048
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Small Molecule Lipid II Inhibitors
Published Friday, February 16, 2018Drug resistance in microorganisms is an urgent and growing concern as more and more microorganisms are found with resistance to commonly used treatments. For bacterial infections alone, approximately 2 million people are infected a year and 23,000 deaths can be directly correlated to drug-resistant bacteria (CDC). There is an urgent need for...
Investigator(s): Eric DeLeeuw, Jamal Chauhan, Steven Fletcher, Alexander MacKerell
Categories: Therapeutics, Small molecules
Keyword(s): Anti-infective
Docket: ED-2016-042
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Hyper-glycosylated Antibodies with Selective Fc Receptor Binding
Published Friday, February 16, 2018This technology is a set of hyper-glycosylated antibodies that have been modified in the Fc domain of the antibody to either enhance or reduce the affinity of the Fc region to the Fc γ...
Investigator(s): Eric Sundberg, Beatriz Trastoy-Bello
Categories: Therapeutics, Biologics
Keyword(s): Immunology
Docket: ES-2013-128
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Giant obscurins and their uses in cancer prognosis and therapy
Published Wednesday, February 7, 2018Approximately 20% of cancer patients diagnosed annually in the US have metastatic cancer, which is associated with much poorer prognoses compared to patients with localized disease. Accurately determining which patients are at risk of developing metastases is a major clinical challenge. Giant obscurins, encoded by the single obscn gene, are...
Investigator(s): Aikaterini Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos, Marey Shriver, Nicole Perry
Categories: Biomarker, Therapeutics, Biologics
Keyword(s): oncology, antibody
Docket: AK-2013-059
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Stable Immunogen Based on Inner Domain of HIV-1 GP120 for Inducing Immunity Against HIV
Published Monday, February 5, 2018Antiviral therapy and prevention strategies have made a tremendous impact on the spread of Human Immunodeficiency Virus (HIV-1). However, an HIV vaccine is highly sought after to treat and prevent HIV. This technology is a set of stable protein immunogens comprised of portions of the inner domain of the HIV-1 gp120 protein for potential...
Investigator(s): Marzena Pazgier, William Tolbert, Neelakshi Gohain, George Lewis
Categories: Vaccines
Keyword(s): vaccine, HIV
Docket: MP-2014-131
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Protective Vaccine & Diagnostic for Acinetobacter baumannii Infection
Published Thursday, February 1, 2018Bacterial infections often persist due to the formation of protective biofilms, which reduce the effectiveness of antimicrobial agents and immune effectors. Acinetobacter baumannii (A. baumannii) is an opportunistic, gram-negative bacteria that is associated with infections in health care settings and...
Investigator(s): Mark Shirtliff, Janette Harro
Keyword(s): vaccine, diagnostic
Docket: MS-2017-032
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Maryland Intersection and Interchange Design & Capacity Analysis Program (MIDCAP)
Published Monday, January 29, 2018The Maryland Intersection and Interchange Design & Capacity Analysis Program (MIDCAP) is a tool to analyze capacity/ queuing for signalized intersections and interchanges, signal and shoulder bypass lane warrants, left turn phase guidlines, and provide lighting evaluation at the preliminary, planning, or design stage.
Categories: Software + Algorithm
Keyword(s): intersection, interchange, design, capacity, analysis
Docket: IS-2017-085