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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Discriminative Facial Verification Software
Published Monday, January 29, 2018In recent years, the performance of face verification systems has significantly improved using deep convolutional neural networks (DCNNs). A typical pipeline for face verification includes training a deep network for subject classification with softmax loss, using the penultimate layer output as the feature descriptor, and generating a cosine...
Categories: Software + Algorithm
Keyword(s): machine learning, neural networks, facial recognition, face verification
Docket: IS-2017-039
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Low-Cost Commodity Camera Array for Acquiring Virtual Environments
Published Monday, January 29, 2018Creating effective augmented and virtual reality (AR and VR, respectively) environments requires understanding the environment that is to be augmented or created. Traditionally, designers curate an augmented environment to display the desired content. This method has been successful in controlled situations such as virtual tourism and...
Categories: Software + Algorithm, Engineering
Keyword(s): virtual reality, camera, camera array, environment acquisition
Docket: IS-2016-043
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MyDesign®
Published Monday, January 29, 2018The education market is rapidly undergoing transformation from a brick-and-mortar classroom to a hybrid model of classroom and distance learning instruction. Since the first Massively Open Online Course (MOOC) in 1969, a variety of technologies have been developed to support curriculum and instruction. Concurrently, policies have been developed...
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): 525
Docket: IS-2017-007
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Small molecule inhibitors of the Mcl-1 oncoprotein based on a 1-hydroxy-2-naphthoate scaffold
Published Monday, January 29, 2018Myeloid cell leukemia-1 (Mcl-1) is an oncoprotein over-expressed in multiple human cancers and is responsible for resistance to conventional anti-cancer agents. An anti-apoptotic member of the Bcl-2 protein family, Mcl-1 plays a major role in the homeostasis of cell proliferation and cell death. The cell-killing function of the pro-apoptotic...
Investigator(s): Steven Fletcher, Maryanna Lanning, Lijia Chen
Categories: Therapeutics, Small molecules
Keyword(s): oncology
Docket: SF-2014-103
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Anthrax toxin protective antigen proteins engineered to target membrane-anchored serine proteases overexpressed on tumor cells
Published Friday, January 26, 2018Bacillus anthracis is the bacterium that produces the anthrax toxin, which consists of the three distinct proteins protective antigen (PrAg), lethal factor (LF), and edema factor (EF). In order for the toxin to be activated, the PrAg moiety of the toxin must bind to cell-surface proteins and become proteolytically cleaved by the proprotein...
Investigator(s): Toni Antalis, Erik Martin
Categories: Therapeutics, Biologics
Keyword(s): oncology, protein therapy, anthraz, ZMT
Docket: TA-2016-015
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Prompt Gamma Imaging System for Proton Range Verification using a Compton Camera
Published Tuesday, December 12, 2017Range uncertainty in the exact position of the distal dose gradient of a proton beam delivered within a patient during radiotherapy (RT) can lead to underdosing of the tumor or to excessive dosing to adjacent healthy tissues or critical organs at risk. The unwanted side effects and complications due this uncertainty is...
Investigator(s): Jerimy Polf
Keyword(s): Radiation Oncology, Medical Imaging, Theranostics, Radio-isotope monitoring/imaging, Prompt Gamma Imaging System
Docket: JP-2017-058, JP-2016-088, JP-2015-137
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Wnt Signaling Inhibitors for the Treatment of Diabetes
Published Tuesday, December 12, 2017The Wnt/β-catenin signaling pathway plays a pivotal role in cell proliferation and differentiation through the regulation of the transcriptional factor β-catenin. The Wnt pathway has been studied extensively for cancer (colon, liver) but the role of the Wnt...
Investigator(s): Fengtian Xue, Yan Shu
Keyword(s): Metabolic Disease, diabetes, small molecule inhibitor
Docket: FX-2015-082
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Automated evaluation of surgeon technical performance
Published Wednesday, November 15, 2017The technical skills of a surgical resident are typically evaluated by experienced mentors during training. However, this process is time-consuming, labor-intensive and may involve evaluator biases. In an effort to standardize such technical evaluations, UMB researchers developed an automated, sensor-free...
Investigator(s): Colin Mackenzie, Peter Hu, Shiming Yang, Evan Garofalo
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): surgery, education, assessments
Docket: CM-2016-014
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The HIV Transgenic (Male/Female) Rat, HIV type 1 (HIV-1) transgenic (Tg) rat on the Fisher 344 background
Published Thursday, November 2, 2017The HIV-1 Tg rat exhibits expression of the transgene, consisting of an HIV-1 provirus with a functional deletion of gag and pol, is regulated by the viral long terminal repeat. Spliced and unspliced viral transcripts were expressed in lymph nodes, thymus, liver, kidney, and spleen, suggesting that Tat and Rev are...
Investigator(s): Joseph Bryant, William C Reid, Harry G.Davis Jr.
Categories: Biomaterials
Keyword(s): biological materials, HIV-1
Docket: JB-2010-136-1
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Histatin-5-Based Antifungal Peptides for Oral Topical Applications
Published Tuesday, October 31, 2017Candida albicans is a fungus colonizing human mucosal surface. It commonly causes recurrent infections which can become life-threatening in immunosuppressed and immunocompromised patients. Histatin-5 (Hst-5) is a cationic antimicrobial peptide found in saliva with antifungal activity against C. albicans, related fungal...
Investigator(s): Mary Ann Jabra-Rizk, Amy Karlsson, Timothy F. Meiller
Categories: Therapeutics, Biologics
Keyword(s): Candida, fungus, Biofilm, antimicrobial
Docket: MR-2016-100