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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Vaccine for Prevention of Sepsis and Broad Protection Against Gram-Negative Bacterial Infections
Published Wednesday, May 28, 2014The “J5dLPS/OMP” vaccine, created by academic and federal research collaborators led by Prof. Alan Cross, is a clinical-stage vaccine for the prevention of sepsis and protection against infection by a wide variety of Gram-negative bacteria. The vaccine comprises detoxified core lipopolysaccharide from Escherichia coli J5 complexed with...
Investigator(s): Alan Cross, Apurba Bhattacherjee, Wendell Zollinger, Steven Opal
Categories: Vaccine
Keyword(s): vaccine, gram-negative infection, sepsis prevention
Docket: AC-2006-005
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Live Attenuated Salmonella Paratyphi A Vaccine
Published Wednesday, May 28, 2014With the emergence of antibiotic resistant strains and increase in frequency of enteric fever caused by Salmonella enterica serovar Paratyphi A, there is a critical need for a prophylactic vaccine, as none is currently available. Typhoid fever and paratyphoid fever are clinically indistinguishable, patients having a rash and fever which can...
Investigator(s): Chris Vindurampulle, Eileen Barry, Myron Levine
Categories: Vaccine
Keyword(s): vaccine, paratyphoid
Docket: CV-2006-034
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Salmonella Based Oral Vaccines for Anthrax
Published Thursday, May 29, 2014Recent heightened awareness of the possibility of bioterrorism has raised concerns about the use of Bacillus anthracis or related strains as bio-weapons. Anthrax is an infection caused by the spore-forming bacterium B. anthracis, which can enter the body and cause infection by means of inhalation, ingestion, or subcutaneous exposure. There is a...
Investigator(s): Leslie Baillie
Categories: Vaccine
Keyword(s): Anthrax, vaccine, salmonella
Docket: LB-2010-092
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Vaccine Enabling Technologies
Published Thursday, May 29, 2014Bacterial live vector vaccines represent a strategy offering exceptional flexibility for vaccine development. In this approach, genes that encode foreign antigens of unrelated bacterial, viral, or parasitic pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby...
Categories: Bioengineering, Vaccine
Keyword(s): vaccine
Docket: Multiple Docket Numbers
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Immunotherapeutic Potential of Modified Lipooligosaccharides/Lipid A: A Platform for “Custom-designed Adjuvants”
Published Wednesday, November 12, 2014Lipid A, the hydrophobic anchor of lipopolysaccharide (LPS), can stimulate the innate immune system via Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2), leading to the release of inflammatory cytokines/chemokines and type I interferons. In turn, this response increases the host’s ability to eradicate a pathogen and supports...
Investigator(s): Robert K Ernst, Adeline Hajjar, Mark Pelletier
Categories: Platforms, Biologics, Vaccines, Biological, Vaccine, Other
Keyword(s): adjuvant, subunit vaccine, lipid A, platform, lipopolysaccharide, immunostimulation custom synthesis
Docket: RE-2012-067
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In situ determination of alum filling evenness and sedimentation in pharmaceutical products using water NMR
Published Wednesday, May 17, 2023Summary The invention describes a fast and non-destructive technique to determine the evenness of alum particle filling levels and/or...
Investigator(s): Bruce Yu, Christopher Fox, Marc Taraban
Categories: Diagnostics, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing
Docket: BY-2019-021
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Detection of Pharmaceutical Product Freezing History using Water Proton NMR
Published Wednesday, May 17, 2023Summary Researchers at UMB have created an innovative method that employs water proton nuclear magnetic resonance (NMR) spectroscopy to detect the freezing history of pharmaceutical products. This technology compares the...
Investigator(s): Bruce Yu, Marc Traban, Katharine Briggs
Categories: Devices, Therapeutics, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2019-081
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079